00000cam 2200000zi 4500 9.964884 CaOODSP 20260807110247 m o d f cr cn |||||||| 260806e202608##qucd ob f000 0 eng d 9781100000817 CaOODSP eng rda CaOODSP n-cn--- En84-402/2026E-PDF Science approach document : bioactivity exposure ratio : application in priority setting and risk assessment : technical updates / Health Canada. Gatineau, Quebec : Government of Canada = Gouvernement du Canada, August 2026. ©2026 1 online resource (17 pages) : charts text txt rdacontent computer c rdamedia online resource cr rdacarrier Issued also in French under title: Document sur l’approche scientifique - ratio de l’exposition bioactive : l’application à l’établissement des priorités et à l’évaluation des risques : mises à jour techniques. Includes bibliographical references (pages 16-17). "The SciAD demonstrated the utility of in vitro bioactivity data in quantitative risk-based prioritization and assessment for human health. However, the approach is regarded as dynamic, and it continues to evolve as new sources of information become available and research progresses. Provided in this document are the modifications and updates to the overall BER approach since the SciAD was first published in 2021 (Health Canada, 2021). Some updates have been made in response to the public feedback on the approach, while others relate to advances in the interpretation and use of in vitro data to derive a bioactivity threshold. The revisions cover 3 broad areas, namely: version updates to databases and tools; changes to in vitro assay filtering criteria; and consideration of in vitro distribution"--page 4. Biological assay. Toxicity testing In vitro. Canada. Environment and Climate Change Canada, issuing body. Canada. Health Canada, issuing body. Document sur l’approche scientifique : (CaOODSP)9.964883 PDF 509 KB https://publications.gc.ca/collections/collection_2026/eccc/En84-402-2026-eng.pdf EC2026