Screening assessment for the Challenge Benzene, 1-chloro-2-[2,2-dichloro-1-(4-chlorophenyl)ethyl]- (Mitotane) : Chemical Abstracts Service Registry Number 53-19-0. : En14-284/2017E-PDF

"Mitotane is a substance that may be formed upon the degradation of dichlorodiphenyltrichloroethane (DDT) and may be present as residual in DDT and dicofol, two active ingredients formerly found in pest control products that are no longer registered for use in Canada. Residues of both DDT and dicofol may still be found in soil and sediment. Additionally, mitotane is registered for use in Canada as a chemotherapeutic agent for the treatment of adrenal cancer. The substance is not naturally occurring and is not manufactured in Canada. Between 100 and 1000 kg of mitotane were imported into Canada in 2005. Mitotane was not reported to be imported in 2006 above the reporting threshold of 100 kg nor used above the reporting threshold of 1000 kg. The pharmaceutical industry provided information that indicates that quantities imported and used in Canada is in the range of 100 to 1000 kg per year. Its use as a chemotherapeutic agent suggests that it could be released into the Canadian environment"--Synopsis, p. [i].

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