Science approach document : bioactivity exposure ratio : application in priority setting and risk assessment : technical updates / Health Canada. : En84-402/2026E-PDF

"The SciAD demonstrated the utility of in vitro bioactivity data in quantitative risk-based prioritization and assessment for human health. However, the approach is regarded as dynamic, and it continues to evolve as new sources of information become available and research progresses. Provided in this document are the modifications and updates to the overall BER approach since the SciAD was first published in 2021 (Health Canada, 2021). Some updates have been made in response to the public feedback on the approach, while others relate to advances in the interpretation and use of in vitro data to derive a bioactivity threshold. The revisions cover 3 broad areas, namely: version updates to databases and tools; changes to in vitro assay filtering criteria; and consideration of in vitro distribution"--page 4.

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